CEA (Carcinoembryonic Antigen)

Ref: AP10019C – Clone: Col-1 – Host: Mouse – Method: P – Format: Concentrated

SKU: AP10019C Category: Tag:

Description

SUMMARY, EXPLANATION AND LIMITATIONS:
CEA consists of a heterogeneous family of related oncofetal glycoproteins with molecular weights of approximately 200 kDa. It is secreted into the glycocalyx of gastroinstestinal cells. CEA is expressed by foetal epithelial cells and to some extent by adult epithelial cells. Immunohistochemical detection of CEA helps to differentiate between mesotheliomas and pulmonary adenocarcinomas as well as between liver cell carcinomas and carcinomas of other origin metastasing to the liver. It also allows for discrimination of endocervical adenocarcinomas (predominantly positive for CEA) from adenocarcinomas of the endometrium (seldom positive for CEA, Castrillon DH et al., McCluggage WG et al.). Medullary thyroid carcinomas, gastrointestinal carcinomas (including pancreatic carcinomas) as well as pulmonary adenocarcinomas stain mostly positive for CEA. Ductal and lobular breast carcinomas are sometimes positive, whereas carcinomas of the ovary and kidney are rarely positive for CEA (Kaufmann O et al., Lagendijk JH et al.). Very rarely CEA is detectable in myelomas (Pertruch UR et al.).

Clone: Col-1
Isotype: IgG2a
Immunogen: Purified protein from human colon carcinoma.
Staining pattern: Cytoplasmic and luminal membrane.
Positive control: Tissue sample from colon adenocarcinoma.

APPLICATIONS:
This antibody is designed for the specific localization of human CEA using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
Immunohistochemical detection of CEA helps to differentiate between mesotheliomas and pulmonary adenocarcinomas as well as between liver cell carcinomas and carcinomas of other origin metastasing to the liver. It also allows for discrimination of endocervical adenocarcinomas (predominantly positive for CEA) from adenocarcinomas of the endometrium.