Cyclin D1

Ref: AP10158C – Clone: SP4 – Host: Rabbit – Method: P – Format: Concentrated

SKU: AP10158C Category: Tag:

Description

SUMMARY, EXPLANATION AND LIMITATIONS:
Cyclin D1 or PRAD-1 or bcl-1 is one of the key cell cycle regulators, and functions in association with cdk4 and / or cdk6 by phosphorylating the Rb protein. It is a putative protooncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL).

Clone: SP4
Isotype: IgG
Immunogen: A synthetic peptide from C-terminus of human cyclin D1.
Staining pattern: Nuclear.
Positive control: Tissue sample from mantle cell lymphoma.

APPLICATIONS:
This antibody is designed for the specific localization of human cyclin D1 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.