SUMMARY, EXPLANATION AND LIMITATIONS:
Cell adhesion to extracellular matrix is an important physiological stimulus for organization of the actin-based cytoskeleton. Adhesion to the matrix glycoprotein Thrombospondin-1 triggers the sustained formation of F-Actin microspikes that contain the Actin-bundling protein Fascin. These structures are also implicated in cell migration, which may be an important function of Thrombospondin-1 in tissue remodeling and wound repair. Fascin bundles Actin microfilaments within dynamic cellular structures such as microspikes, stress fibers and membrane ruffles. It may serve as a prognostic factor for abnormal ovarian epithelial pathology and may be a novel target for the treatment of ovarian cancer. An Actin-bundling protein, Fascin identifies dendritic cells in the blood and in tissues.
Immunogen: ImmunogenFull length native protein (purified from HeLa cells) (Human).
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from Hodgkin lymphoma or spleen.
This antibody is designed for the specific localization of human Fascin using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.