SUMMARY, EXPLANATION AND LIMITATIONS:
The catenins (alpha, Beta and gamma) are ubiquitously expressed, cytoplasmic proteins associated with E-cadherin at cellular junctions. b-catenin also binds to N-cadherin and co-immunoprecipitates with APC. Cadherin/catenin complexes are linked to the cytoskeleton via a direct association between alpha-actinin and alpha-catenin. Increases tyrosine phosphorylation can disrupt catenin-cadherin complexes, influencing cellular adhesion.
Immunogen: A 92kDa synthetic peptide from the C-terminus of the b-catenin protein.
Staining pattern: Cytoplasmic and cell membrane.
Positive control: Tissue sample from breast or skin.
This antibody is designed for the specific localization of human b-Catenin using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.