SUMMARY, EXPLANATION AND LIMITATIONS:
The c-Met oncogene was originally isolated from a chemical carcinogen-treated human osteogenic sarcoma cell line by transfection analysis in NIH/3T3 cells. The Met proto-oncogene product was identified as a trans-membrane receptor-like protein with tyrosine kinase activity that is expressed in many tissues. The c-Met gene product has been identified as the cell surface receptor for hepatocyte growth factor, a plasminogen-like protein thought to be a humoral mediator of liver regeneration.
Immunogen: Synthetic peptide from C-terminus of human c-Met protein.
Staining pattern: Cytoplasmic and cell membrane.
Positive control: Tissue sample from breast carcinoma.
This antibody is designed for the specific localization of human c-Met using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.