SUMMARY, EXPLANATION AND LIMITATIONS:
Cadherins are calcium dependent cell adhesion molecules, which play important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. In adhesion junctions, cadherins are bound to β and γ catenins, which in turn bind to α catenin, an actin binding protein. Cadherins play important role in tumor invasion and metastasis.
Immunogen: A synthetic peptide from the C-terminus of chicken N-cadherin.
Staining pattern: Cell membrane.
Positive control: Tissue sample from tonsil or skin.
This antibody is designed for the specific localization of human cadherina pan using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.