SUMMARY, EXPLANATION AND LIMITATIONS:
Calcitonin is a 32 amino acid peptide which can be detected in C cells of the normal and hyperplastic thyroid. Staining of calcitonin may be used for the identification of C cell derived abnormalities ranging from C cell hyperplasia to invasive tumours. In medullary carcinoma of the thyroid calcitonin can be identified as a fine granular pattern in the cytoplasm. Amyloidal deposits in the tumour may also show varying amounts of calcitonin.
Immunogen: Synthetic peptide of 32 amino acid residues corresponding to human calcitonin.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from thyroid or medullary thyroid carcinoma.
This antibody is designed for the specific localization of human calcitonin using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
Calcitonin staining may be used in the identification of hyperplastic C cells and the tumors they create, including invasive neoplasms. Some epithelial and neuroendocrinal tumours can segregate ectopic calcitonin, making this antibody useful for their study.
Amyloid deposits present in these tumours can exhibit varying levels of positivity in the presence of this antibody.