SUMMARY, EXPLANATION AND LIMITATIONS:
Calretinin is a vitamin D-dependent calcium-binding protein involved in calcium signaling. It is expressed in the central and peripheral nervous system and in many normal and pathological tissues. It stains Mesothelioma and can be used to help differentiate lung tumors. Calretinin is also considered an important diagnostic tool in the differential diagnosis of cystic and solid Ameloblastic Tumors.
Anti-calretinin has been shown to be useful in differentiating Mesothelioma from Adenocarcinomas of the lung and other sources. It is also useful in differentiating adrenal-cortical neoplasms from Pheochromocytomas.
Immunogen: Recombinant full-length mouse calretinin protein.
Staining pattern: Cytoplasmic and nuclear.
Positive control: Tissue sample from mesothelioma.
This antibody is designed for the specific localization of human calretinin using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
The positivity of this antibody in mesothelioma is very high used to identify this type of tumor and its differential diagnosis with other malignant tumors. However described occasional positivity for calretinin other tumors as is the case meloblastomas, tumors of sex cord stromal cell ovarian and testicular Sertoli-Leydig.