SUMMARY, EXPLANATION AND LIMITATIONS:
CD23 is a 45kDa glycoprotein that acts as a receptor for IgE. It is expressed by interleukin-4 activated B-lymphocytes, by activated macrophages, and by a proportion of follicular dentritic cells. CD23 has been shown to be useful for the differentiation of small lymphocytic lymphomas and mantle cell lymphoma.
Immunogen: Recombinant external domain of CD23 protein.
Staining pattern: Cell membrane.
Positive control: Tissue sample from tonsil.
This antibody is designed for the specific localization of human CD23 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
CD23 expression was detected in neoplastic lymphoid cells of chronic lymphocytic leukemia B (73-90% of cases), a variable percentage of follicular lymphomas and in a small proportion of large cell lymphomas, in this case and coinciding with the coexpression of CD40 as a way indicative of better prognosis.
Furthermore and although the CD23 molecule is produced by B cells is adsorbed in large quantity on follicular dendritic reticulum cells thus is also used for the identification of their tumors (dendritic reticulum cell sarcoma).