SUMMARY, EXPLANATION AND LIMITATIONS:
CD4, a single chain transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV.
Immunogen: Stimulated human leukocytes.
Staining pattern: Cell membrane.
Positive control: Tissue sample from tonsil.
This antibody is designed for the specific localization of human CD4 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.