SUMMARY, EXPLANATION AND LIMITATIONS:
This antibody reacts strongly with EBV-positive lymphoblastoid cell lines and EBV infected B cell immunoblasts in infectious mononucleosis. It also reacts with 25 to 50 per cent of EBV-associated undifferentiated nasopharyngeal carcinomas and with Reed Sternberg cells in approximately 90% of EBV-associated Hodgkin’s disease cases. The cocktail recognizes distinct epitopes on the hydrophilic carboxyl region of LMP which is exposed to the cytosol.
Immunogen: EBV-encoded recombinant latent membrane protein.
Staining pattern: Cytoplasmatic.
Positive control: Sample from EBV-infected tissues.
This antibody is designed for the specific localization of EBV using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.