SUMMARY, EXPLANATION AND LIMITATIONS:
Factor XIII in both reduced and non-reduced forms. It does not react with human Factor XIII B-chain or human Factor XII. Factor XIII is a β-globulin found in plasma and is composed of two subunits. Factor XIII-A is the catalytic subunit and is a dimmer of M.W. 160kDa. Factor XIII is present in plasma as an α2β2 heterodimer (M.W. 320kDa); whereas in platelets, only the α2 unit exists. Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system. Factor XIII has also been used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans.
Immunogen: Recombinant protein corresponding to A-subunit of coagulation Factor XIII.
Staining pattern: Nuclear, cytoplasmic.
Positive control: Tissue sample from capillary hemangiomas, dermatofibromas and placenta.
This antibody is designed for the specific localization of human Factor XIIIa using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.