SUMMARY, EXPLANATION AND LIMITATIONS:
FSH is a pituitary hormone involved in the maturation of ovarian follicles and estrogen secretion in females. In the pituitary gland, FSH is produced by gonadotrophs. In males, FSH stimulates the secretion of testosterone.
Immunogen: Purified human FSH-β.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from adenohypophysis.
This antibody is designed for the specific localization of human FSH using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
Normal cells of the adenohypophysis are arranged in columns and nests surrounded by basement membrane and reticulin fibers and H &E staining there are three types of cells: acidophil (40%), basophilic (10%) and chromophobe (50%). Immunohistochemically the adenohypophysis contains five main types of cells that secrete six different hormones: 50% somatotrophs (GH-producing cells), 20% lactotrope (prolactin-secreting cells), 15-20% corticotrophs (ACTH-producing cells), 5% tireotropas (TSH-producing cells), gonadotropic 10% (cells that produce both FSH and LH-or independently). In the pars tubularis is possible to find cells producing FSH and LH. FSH can be used to distinguish: adenomas of FSH-producing cells, giant cell adenomas, null cell adenomas and oncocytic cells that normally express focally FSH and/or LH as well as any growth of gonadotropic origin.