SUMMARY, EXPLANATION AND LIMITATIONS:
Glucose is fundamental to the metabolism of mammalian cells. Several glucose transporter proteins (Glut) isoforms have been identified and shown to function in response to insulin and IGF-1 induced signaling. GLUT-1 is detectable in many human tissues including those of the colon, lung, stomach, esophagus, and breast. GLUT-1 immunoreactivity in some cancers, including transitional cell carcinoma of the urinary bladder, has been associated with aggressive behavior.
Immunogen: Synthetic peptide derived from C-terminal of human GLUT-1 protein.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from breast carcinoma.
This antibody is designed for the specific localization of human GLUT-1 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.