SUMMARY, EXPLANATION AND LIMITATIONS:
Helicobacter pylori is a gram-negative helical bacteria. It is characterized for synthetize urease, an enzyme which protects from the gastric acids. Microorganisms are placed either superficially and/or inside pyloric cells from the stomach mucosa. Nowadays, this bacteria is known as an important cause of gastrointestinal diseases. Its infection is characterized for chronic atrophic gastritis, peptide ulcer and gastro duodenal reflows. Also, the infection is related with lymphomas, gastric adenocarcinomas and lymphoid hyperplasia (MALT lymphoma).
The bacteria can persist for years. In most of cases infection remains asymptomatic for a long period of time, but the stomach mucosa does change. This causes chronic inflammation and later actives chronic gastritis which can causes stomach and duodenal ulcer.
Immunogen: Helicobacter pylori.
Staining pattern: Staining of Helicobacter pylori.
Positive control: Tissue sample from stomach infected with Helicobacter pylori.
This antibody is designed for the specific localization of human Helicobacter pylori using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
Calcitonin staining may be used in the identification of hyperplastic C cells and the tumors they create, including invasive neoplasms. Some epithelial and neuroendocrinal tumours can segregate ectopic calcitonin, making this antibody useful for their study.
Amyloid deposits present in these tumours can exhibit varying levels of positivity in the presence of this antibody.