SUMMARY, EXPLANATION AND LIMITATIONS:
Inhibins are hormones which are produced in the granulose cells of the feminine follicles and in Sertoli cells of the masculine seminiferous tubules. They are specifically expressed by the stromal derivation of the sex cords and they inhibit the follitropin secretion by pituitary gland. Inhibin is formed by two subunits (α and β subunits) which are linked by a disulfide bond. Two forms of inhibin differ on the β subunit (A or B) while the α subunit is identic. Inhibins belong to the TGFβ family.
Immunogen: Synthetic peptide corresponding to the 1-32 amino terminal peptide of the alpha subunit of human inhibin.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from placenta o testis.
This antibody is designed for the specific localization of human inhibin α using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
Inhibin α subunit is strongly expressed in normal placenta, hydatidiform moles, trophoblastic tumors and choriocarcinomas. It can be very useful in the differential diagnosis of gestational trophoblastic injuries and gestational neoplasms. The positivity for the inhibin α is restricted to syncytiotrophoblast, being nevative to cytotrophoblast. Alpha inhibin is detected in primordial ovarian follicle, in granulose tumor cells and stromal tumors from the sex cord. Alpha subunit is not expressed in benign tumors or mucinous or serous malign tumors. It does not shows immunostain with the inhibin α subunit, cervix or endometrial carcinoma. Adrenal cortex shows positivity.