SUMMARY, EXPLANATION AND LIMITATIONS:
Within the adult kidney Kidney-specific Cadherin (Ksp-Cadherin or Cadherin 16) is found exclusively in the epithelial cells of distal tubules and collecting ducts. Clear cell and papillary renal cell carcinoma (RCC) are thought to be of proximal tubular origin. Markers like RCC and CD10 have been shown to be useful for detection of these neoplasms. In contrast chromophobe RCC and oncocytoma are derived from distal tubules and can be stained specifically with Ksp-Cadherin. Shen et al. describe Ksp-Cadherin as a sensitive marker for the distal portion of the nephron and deduced tumours (chromophobe RCC and oncocytoma). They suggest a combination of Ksp-Cadherin and “RCC” to cover both proximal and distal line of differentiation and thus improve the diagnosis of both primary and metastatic renal tumours.
Staining pattern: Cell membrane and cytoplasm.
Positive control: Tissue sample from kidney.
This antibody is designed for the specific localization of human KSP-Cadherin using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.