SUMMARY, EXPLANATION AND LIMITATIONS:
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
Immunogen: A synthetic peptide corresponding to the C-terminal region of human N-cadherin.
Staining pattern: Cell membrane.
Positive control: Tissue sample from pituitary or kidney.
This antibody is designed for the specific localization of human N-cadherin using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.