SUMMARY, EXPLANATION AND LIMITATIONS:
Cells which are selected for the resistance of a cytotoxic drug can be resistant to a wide drugs variety with different structures and target cells. This phenomenon is called Multiple Drugs Resistance (MDR). MDR proteins belong to a highly conserved transporter superfamily which binds ATP. MDR proteins are ATP-depending bombs which transport a variety of structural different agents, from ions to peptides. They are involved in the multiple drugs resistance development observed in human cancer cells after a long chemotherapy. The classic form of multidrug is the increase of the MDR protein level, but not in all multidrug cases.
MDR-1, also called P-glycoprotein, is a transmembrane protein, which stains the blood-brain barrier and works like a bomb transporting a variety of agents. In human population there are 15 polymorphisms on the MDR-1 gen.
Immunogen: Multidrug-resistant Chinese hamster ovary cell line (CHrC5).
Staining pattern: Cell membrane.
Positive control: Tissue sample from liver or colon.
This antibody is designed for the specific localization of human P-Glycoprotein using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.