SUMMARY, EXPLANATION AND LIMITATIONS:
p504S is an enzyme involved in the ß-oxidation of branched-chain fatty acids. Expression of p504S protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It has also been found to stain premalignant lesions of the prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. p504S can be used as a positive marker for PIN. It may be useful to confirm the diagnosis of small foci of prostate carcinoma in needle biopsies. p504S stains the majority prostate cancer; however, p504S has been shown to stain many other types of carcinoma such as hepatoma, breast carcinoma, pancreatic islet tumor and desmoplastic small round cell tumor (Miller and Tacha). HMW CK and p63 may serve as a useful panel.
Immunogen: Synthetic human AMACR peptide.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from prostate carcinoma.
This antibody is designed for the specific localization of human p504S using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.