PIWIL1

Host Mouse
Clone zm211
Format Concentrate
Method IHC
Pretreatment Citrate or Edta
Positive Control Lymph Node of Hairy Cell Leukemia
Dilution 1:100 – 1:200
Isotype IgG2AILC
Inmunogen Recombinant Full-Length Human Annexin
Localization Nucleous, Cytoplasm or full Membrane
SKU: AP100228 Category:
 

Description

Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle

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