SUMMARY, EXPLANATION AND LIMITATIONS:
PMS2 belongs to the mismatch repair proteins (MMR proteins) like MLH1, MLH3, MSH2, MSH3, MSH4, MSH5, MSH6, and PMS1. The PMS2 gene is homologue to the prokaryontic MutL gene. Defects in the genes coding for MMR proteins lead to microsatellite instability (MSI) and considerable higher mutation rates. Hereditary nonpolyposis colorectal cancers (HNPCC) often show germline mutations in the mmr protein associated genes. These mutations result in decreased or abnormal protein production. The majority of HNPCC is characterised by damages in the MLH1 and MSH2 encoding genes, sometimes also in damages in MSH6 and PMS2 encoding genes.
Immunogen: Recombinant human PMS2 (C-Terminus).
Staining pattern: Nuclear.
Positive control: Tissue sample from placenta or colon adenocarcinoma.
This antibody is designed for the specific localization of human PMS2 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.