SUMMARY, EXPLANATION AND LIMITATIONS:
The determination of steroid hormone receptors is of great importance for therapy of patients with hormone receptor expressing tumours. Progesterone and estrogen receptor positive breast carcinoma patients have demonstrated a better response to endocrine therapy than receptor negative patients. Expression of progesterone receptors in tumour cells of human breast carcinoma points to an intact estrogen receptor and to sensitivity of this tumour to endocrine therapy. Several investigations have shown that progesterone receptor is a better prognostic marker than estrogen receptor.
Immunogen: Recombinant protein corresponding to amino acid residues 412-526 of human PR.
Staining pattern: Nuclear.
Positive control: Tissue sample from breast carcinoma.
This antibody is designed for the specific localization of human PR using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.