SUMMARY, EXPLANATION AND LIMITATIONS:
The rate of parathormone secretion is directly responsive to the level of calcium in the serum, and indeed the cytoplasm, of parathyroid cells, as has been shown by studies both in vivo and in vitro.
Anti-PTH antibody is useful to distinguish parathyroid hyperplasia/neoplasms from thyroid and metastatic neoplasms; although the pathologist is typically aware of the preoperative hypercalcemic status. Occasionally when the surgeon does not supply this information PTH immunohistochemistry is essential. Even more problematic, are situations in which clear cell parathyroid carcinomas are nonsecretory without an abnormality in mineral metabolism.
Isotype: IgG2a Kappa
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from parathyroid gland.
This antibody is designed for the specific localization of human PTH using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.