SUMMARY, EXPLANATION AND LIMITATIONS:
TIA-1 (T-cell intracytoplasmic antigen) monoclonal antibody reacts with a 15 kDa cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. The expression of TIA-1 was studied in CD30+ anaplastic large cell lymphomas (ALCL), NK-cell lymphomas and peripheral T-cell lymphomas and T-cell lymphocytosis, B-cell lymphomas and lymphoblastic leukemia, Hodgkin’s etc. Studies showed that 60 to 70% of anaplastic large cell lymphoma reacted with TIA-1. Studies also indicate that TIA-1 reacts with most large granular lymphocytic leukemia’s, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas, pulmonary angiocentric lymphomas of T-or NK-phenotype.
Immunogen: Complete protein TIA-1 human.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from anaplastic large cell lymphoma, tonsil.
This antibody is designed for the specific localization of human TIA-1 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.